- Memory = a brain function.
-
-
- LMTX = Methylene blue
- TauRx Therapeutics - Wikipedia - LMTX is an altered version of Methelene blue.
- Methylene blue - Wikipedia
- LMTX is not effective if combined with other Alzheimer drugs.
- Edutopia
- Everything Zoomer
- What You Should Do - And Not Do - to Reduce Your Risk of Dementia - Everything Zoomer
- Report Suggests Alzheimer’s Research May Have Been Fabricated; What Does This Mean for Diagnosis and Treatment? - Everything Zoomer
- Exercise
- Treat high blood pressure
- Stop smoking
- Treat hearing loss
- Floss your teeth regularly
- Convince your government to fund research
- New Blood Test Detects Alzheimer's Up to 20 Years Before Symptoms Start - Everything Zoomer - 2018-02-01
- The blood test identifies biological markers in blood that show the build-up of the protein amyloid-beta — one of the first signs of Alzheimer's disease. Until now, reports Nature Magazine, the only way to identify amyloid-beta in the brain - short of an autopsy - has been to image the brain using PET scans, or to measure levels of the protein directly in cerebrospinal fluid from the spinal cord. Both of these procedures have been used to help recruit patients into recent trials, but the tests are expensive and uncomfortable.
- Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia | Nature Medicine - 2020-03-02
- Closer to a blood test for Alzheimer disease | Nature Reviews Neurology - 2020-03-18
- Zika Virus May Cause Alzheimer-like Symptoms in Adults - Everything Zoomer
- ExtremeTech
- The Globe and Mail
- Data show just how much exercise can lower Alzheimer’s risk - The Globe and Mail
- A gene variant known as APOE-e4 is thought to play a role in up to one-quarter of Alzheimer’s cases.
- If you want to improve your odds, you should exercise no matter what your genes say.
- A need for change in the unbalanced approach to Alzheimer’s - The Globe and Mail
- 72 per cent of Alzheimer patients are female.
- Age is the biggest risk factor for dementia.
- Women are 2.5 times more likely to suffer from depression than men.
- Only 5 per cent of people with Alzheimer’s are genetically predisposed to have the disease.
- Anxiety may accelerate slide into Alzheimer’s - The Globe and Mail
- Anxiety may accelerate the decline into Alzheimer’s disease in older patients with mild memory problems.
- People with anxiety disorders have higher levels of the stress hormone cortisol, which has been shown to damage the hippocampus, a brain structure important for memory processing and emotion.
- Follow the MIND diet to stave off Alzheimer’s - The Globe and Mail
- Mediterranean diet
- DASH =Dietary Approaches to Stop Hypertension
- MIND diet =Mediterranean-DASH Intervention for Neurodegenerative Delay
- Antipsychotics shouldn’t be a default drug for dementia - The Globe and Mail
- Researchers link common over-the-counter drugs to dementia - The Globe and Mail
- GreenMedInfo.com
- HealthAfter50.com | UC Berkley School of Public Health | Health and Welness Alerts
- HealthLine.com
- 10 Early Symptoms of Dementia: Be Aware of Subtle Signs - Thanks to Mitchell Abbott for recommending this site.
- Neurology | Midlife cardiovascular fitness and dementia | Neurology
- Neurotrack
- Neurotrack, the winning health startup at SXSW — Tech News and Analysis - 2013-03-13 - Neurotrack, a startup built on years of neuroscience research, says it can identify patients at risk for developing Alzheimer’s years before the onset of the condition.
- Neurotrack - Transforming the diagnosis & treatment of Alzheimer’s
- New England Journal of Medicine (NEJM)
- Glucose Levels and Risk of Dementia — NEJM - 2013-08-13
- Higher glucose levels may be a risk factor for dementia, even among persons without diabetes. (NIH)
- Glucose Levels and Risk of Dementia — NEJM - 2013-08-13
- New York Post
- New York Times -|$$$|- (CDN$20/4weeks)
- Reader's Digest = rd.ca
- Telegraph
-
- Addiction ...
- Alzheimer & Dementia
- see also: Dementia
- see also: Memory
- Alzheimer’s disease is just one of 70 causes of dementia (an umbrella term for memory loss due to changes in the brain).
Not everyone who has dementia has Alzheimer’s – it can also be part of Parkinson’s disease or the result of a stroke, for example. - Mild cognitive impairment (MCI) is a condition that, in many cases, is a precursor to Alzheimer's disease.
- Alzheimer Disease (la maladie d'Alzheimer) accounts for 64% of all Dementia cases.
- We all have a 50 percent chance of developing Alzheimer's disease after age 85. Alzheimer's disease is not a normal part of aging.
- Alzheimer’s might not be primarily a brain disease. A new theory suggests it’s an autoimmune condition.
- In July 2022, Science magazine reported that a key 2006 research paper, published in the prestigious journal Nature, which identified a subtype of brain protein called beta-amyloid as the cause of Alzheimer’s, may have been based on fabricated data.
- Dementia= a loss of brain function that occurs with certain diseases.
- Alzheimer Disease = AD is the most common form of dementia. AD is a progressive, degenerative brain disease. AD affects memory, thinking, and behaviour.
- Vascular dementia
- Frontotemporal dementia
- Semantic dementia
- Lewy bodies dementia.
- etc... (It is possible for a patient to exhibit two or more dementing processes at the same time, as none of the known types of dementia protects against the others.)
- Dementia - Wikipedia - la Démence
- Dementia is a serious loss of global cognitive ability in a previously unimpaired person, beyond what might be expected from normal aging. It may be static, the result of a unique global brain injury, or progressive, resulting in long-term decline due to damage or disease in the body. Although dementia is far more common in the geriatric population, it can occur before the age of 65, in which case it is termed "early onset dementia". Dementia is not a single disease, but rather a non-specific illness syndrome (i.e., set of signs and symptoms) in which affected areas of cognition may be memory, attention, language, and problem solving. It is normally required to be present for at least 6 months to be diagnosed; cognitive dysfunction that has been seen only over shorter times, in particular less than weeks, must be termed delirium. In all types of general cognitive dysfunction, higher mental functions are affected first in the process.
- Symptoms of dementia can be classified as either reversible or irreversible, depending upon the etiology of the disease. Less than 10% of cases of dementia are due to causes that may presently be reversed with treatment.
- Alzheimer's disease - Wikipedia
- Alzheimer Society of Canada - Société Alzheimer du Canada
- Alzheimer’s Association (US)
- Alzheimer’s Society (UK)
- Legal & Financial
- Legal and Financial Planning for Alzheimers | RequestLegalHelp.com - Thanks to Destinie Wallis for recommending this site.
- Alzheimer's & Dementia Legal & Financial Resources | Fiscal Tiger - Thanks to Heidi Paris for recommending this site.
- ************
- Causes of Dementia
- Diet - Sugar - Carbohydrates
- mould
- vasculatory/circulatory problems
- chronic hypertension (high blood pressure)
- Aggressively lowering elevated blood pressure significantly reduces the risk of mild cognitive impairment (MCI), and perhaps Alzheimer's disease.
- depression
- Depression may be an early symptom of Alzheimer’s and other forms of dementia.
People who are depressed have an increased risk for cardiovascular and cerebrovascular disease—that is, blockages in the arteries that impede blood flow to the heart and brain.
Although depression was associated with an 85 percent increased risk for dementia from all causes, the risk for vascular dementia was 250 percent.
- Depression may be an early symptom of Alzheimer’s and other forms of dementia.
- vitamin deficiency
- bacteria & Oral hygiene
- Maintaining healthy gums and teeth is important in reducing P gingivalis. Porphyromonas gingivalis causes corroding of the gums and decaying of the teeth. It is a well-known risk factor for heart and artery disease.
- Plaques give every sign of being the brain's protective reaction against inflammation. They're an effect, not a cause, of the illness that's eating up brain cells – the causes most likely being poor sleep (which prevents elimination of brain waste), toxins, chronic infections, allergies and all the other multiple causes of inflammation. In mice, the oral infection was found to penetrate the brain and increase production of amyloid beta, the Alzheimer's-linked protein. Most laypeople just think of it as brain plaque. P gingivalis also produces poisonous enzymes called gingipains which have previously been linked with two other Alzheimer's-associated proteins called tau and ubiquitin.
- How gum disease could lead to Alzheimer's
- Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
- The Cause of Alzheimer's Could Be Coming From Inside Your Mouth : ScienceAlert
- virus
- Herpes - Almost all of us have latent herpes viruses residing dormant within us. The problem comes when they're woken up in the brain by infection, inflammation, a stressful event or a weakened immune system.
- New Evidence Implicates Herpes as a Cause of Alzheimer's – Awakening From Alzheimers
- herpes simplex (HSV1) — the virus responsible for cold sores
- herpes zoster ophthalmicus (shingles affecting the eyes)
- HSV1 sufferers who were treated aggressively with antiviral medication saw the incidence of dementia reduced — by more than ten-fold
- How 2 common viruses may trigger Alzheimer's
- Varicella zoster virus (VZV) is the virus that causes varicella - or chickenpox - in childhood and can cause zoster - shingles - later in life.
- When VZV becomes activated as shingles, it reactivates dormant herpes simplex virus type 1Trusted Source (HSV-1). In 2021, Dr. Itzhaki published a study compiling a significant body of researchTrusted Source showing an association between activated HSV-1 and AD.
- A range of factors has been reported to reactivate HSV-1 from the latent state, including stresses and disease states. Stress, immunosuppression, UV light, and menstruation are possible triggers.
- The authors of the study noted that there is evidence that both HSV-1 and VZV can become activated after COVID-19.
- Cold Sores and Shingles May Be Linked to Alzheimer’s, New Research Indicates | Barron's
- Herpes - Almost all of us have latent herpes viruses residing dormant within us. The problem comes when they're woken up in the brain by infection, inflammation, a stressful event or a weakened immune system.
- genetics?
- Copper (Cu)
- See also: vitamins.htm#traceminerals
- Tap Water May Increase Your Risk of Alzheimer's – Awakening From Alzheimers
- Inorganic copper in drinking water (delivered by copper pipes in the home). Inorganic copper in your bloodstream is called "free copper." And it's NOT good.
- Have your water tested for copper.
- Switch to filtered water.
- The study participants who consumed higher amounts of inorganic copper and who also ate higher amounts of saturated and trans fats suffered a much faster cognitive decline. And the more copper they consumed, the faster their brain functioning went downhill. - Dietary Copper and High Saturated and trans Fat Intakes Associated With Cognitive Decline | Neurology | JAMA Neurology | JAMA Network
- "Organic" copper is the kind you get from the food you eat; it's bound to other elements like carbon and hydrogen. This copper is necessary for the body.
- Copper in multi-vitamins?? Don't take a multivitamin that contains copper. Typical multi-vitamin has 2mg Cu (Copper Sulphate), which is 100% of the daily recommended Cu dose (according to the label).
- The current recommended dietary allowance for copper intake for adults is 0.9 mg/d. However, the study did not find that high copper intake alone was related to cognitive decline. High copper intake was associated with a significantly faster rate of cognitive decline but only among persons who also consumed a diet that was high in saturated and trans fats.
- Hearing loss
- The greater the hearing loss, the greater the chances of developing dementia. Perhaps isolation from other people and resultant lack of physical activity could be involved.
- Isolation, stigma and the resultant lack of physical activity that are linked to hearing and vision problems might have something to do with it.
- Hearing impairment and cognitive decline in senile dementia of the Alzheimer's type. - PubMed - NCBI
- Relationship of hearing impairment to dementia and cognitive dysfunction in older adults. - PubMed - NCBI
- Hearing loss and incident dementia. - PubMed - NCBI
- Hearing impairment and risk of Alzheimer's disease: a meta-analysis of prospective cohort studies. - PubMed - NCBI
- Longitudinal Relationship Between Hearing Aid Use and Cognitive Function in Older Americans. - PubMed - NCBI
- Hearing and visual aids linked to slower age-related memory loss
- Iron ...
- Vision loss
- Sight loss and vision impairment strike more than the eyes alone. They're also linked with cognitive decline and dementia.
- Cataracts - those who accepted surgery had half the rate of cognitive decline compared to those who did not undergo cataract surgery.
- David Perlmutter M.D. - Alzheimer's and Dementia - David Perlmutter M.D.
- A Maverick Scientist has Made an Important New Alzheimer's Discovery – Awakening From Alzheimers
- Guamanian amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) = a hybrid form of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS – also known as Lou Gehrig's disease). Boiled bats contained a high dose of a toxin named BMAA – β-N-methylamino-l-alanine. Bats in Guam, until they became extinct, ate a diet filled with the seeds of cycad trees, which contain BMAA. The BMAA contained in the cycad trees originates in what are called cyanobacteria that grow on the roots of the trees.
- The amino acid L-serine, which is available as a dietary supplement, may help protect against these types of brain problems and lower the risk of Alzheimer's disease. L-serine could possibly boost longevity. In research on the Ogimi inhabitants of Okinawa, some of the longest-living people on earth, a dietary analysis shows that they eat foods – like seaweed – that contain four times as much L-serine as the average American diet.
- Study: These Commonly Prescribed Drugs Are Linked to a Nearly 50% Higher Dementia Rate - Everything Zoomer - anticholinergic drugs (a class of drugs that includes some antidepressants, bladder antimuscarinics, antipsychotics and anti-epileptic drugs).
- etc??
- Cures? for Dementia
- ‘This looks like the real deal’: are we inching closer to a treatment for Alzheimer’s? | Health | The Guardian
- DNA "Scissors" Could Cut Out the Alzheimer's Causing Gene in Mice - CRISPR-Cas9
- FDA Grants Accelerated Approval for Alzheimer's Drug | FDA
- Aduhelm = aducanumab = a monoclonal antibody protein (targeting amyloid plaques) = introvenous treatment to slow (by ~20%) Alzheimer's = by Biogen (~$50,000/year)
- Very very controversial. Effectiveness depends on starting early enough and giving the patients a high enough dose for a long enough time. Side effects (like brain swelling and bleeding) are significant.
- Diet - Ketogenic ...
- A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT - Fortier - - Alzheimer's & Dementia - Wiley Online Library
- Quebec professor's drink to treat mild cognitive impairments in older adults hitting store shelves | CTV News - 30 grams of "medium-chain triglycerides" (MCTs from coconut oil and palm kernel oil) in the form of a liquid dietary supplement. MCTs enhance the body's production of ketones.
- Diet - Ketogenic ...
- A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT - Fortier - - Alzheimer's & Dementia - Wiley Online Library
- Alzheimer's disease: It may be possible to restore memory function, preclinical study finds - University at Buffalo
- Lithium?
- Fasudil?
- Role of Vitamin E in the Treatment of Alzheimer's Disease: Evidence from Animal Models
- The Role of Magnesium in Neurological Disorders
- David Perlmutter M.D. - Alzheimer's and Dementia - David Perlmutter M.D.
- L-serine
- Alzheimer’s breakthrough: British scientists pave way for simple pill to cure disease - Science - News - The Independent
- Vitamin B12 Deficiency Can Cause Symptoms That Mimic Aging - NYTimes.com -|$$$|- (CDN$20/4weeks)
- MayoClinic Home - MayoClinic.com
- Neurobics.com
- Study: Older adults improve memory through exercise – The Chart - CNN.com Blogs
- Predicting and Preventing Dementia
- Exercise ...
- The 6 WARNING Signs of Dementia - YouTube
- Signs: Poor organization and planning, Personality changes, Constipation, Sensory dysfunction, Language problems, Problems navigating
- Prevention: Vitamin B1 (Thiamine) (nutritional yeast), Fix the gut (biome) (low carb diet & fasting), Consume broccoli sprouts, Ketones (fasting, MTC oil), Ginkgo Biloa (EGB 761), Lion's mane mushroom, (Omega-3, Vit.D, Zn=Zinc, Exercise, Sleep)
- Cognitive decline due to ageing can be reversed in mice – here's what the new study means for humans
- It has been known for some years that eating blueberries and other fruit and vegetables, such as strawberries and spinach, improves cognition in rodents and older people. These foods are rich in molecules such as resveratrol, fisetin and in quercetin, which have been shown either to kill or rescue senescent cells.
- Scientists could have a better way to spot early signs of dementia — Quartz
- Ultrasound neck scan to measure the intensity of "carotid artery forward compression waves." This is a measure of the force needed to propel blood to the brain. After taking age, blood pressure, body mass index, diabetes and other cardiovascular conditions into account, the researchers found those with the highest intensity pulses at the start of the study were 50 per cent more likely to suffer accelerated cognitive decline over the following decade. 51856, BHF, BBC-46155607
- Fitness
- Exercising, cutting stress, improving sleep, eating sensibly, and taking a few selected supplements (something as simple as enzymes can help).
- Midlife cardiovascular fitness and dementia | Neurology
- The Association Between Midlife Cardiorespiratory Fitness Levels and Later-Life Dementia
- Brain-derived neurotrophic factor and its clinical implications
- A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor
- How to cut your risk of memory loss - CNN.com
- Daily Consumption of Oregon Hazelnuts Affects a-Tocopherol Status in Healthy Older Adults: A Pre-Post Intervention Study | The Journal of Nutrition | Oxford Academic - (vitamin E, Magnesium)
- L-serine
- Klotho: Could This Protein Actually Be the Key to Longevity? - Everything Zoomer
- Sleep
- Dementia: The greatest health challenge of our time - BBC News
- Research estimates that one in three cases could be prevented by lifestyle changes including:
- treat hearing loss in mid-life
- spend longer in education
- don't smoke
- seek early treatment for depression
- be physically active
- avoid becoming socially isolated
- avoid high blood pressure
- don't become obese
- don't develop type 2 diabetes
- Research estimates that one in three cases could be prevented by lifestyle changes including:
- Many dementias could be prevented if nine lifestyle factors were corrected, resulting in about 30 per cent fewer people with dementia.
- low levels of education
- mid-life hearing loss
- physical inactivity
- high blood pressure
- Type 2 diabetes
- obesity
- smoking
- depression
- social isolation.
- Care / Caring for Alzheimers
- Arts and Crafts for People with Alzheimer's | FindReviews - Thanks to Graham Cook for recommending this site.
- Alzheimer's Caregivers | MedlinePlus
- ************
- Alzheimer’s Breakthrough: Genetic Link to Gut Disorders Confirmed - Neuroscience News
- The Most Promising Research in the Race for a Dementia Cure - Everything Zoomer
- LATE
- Awakening From Alzheimers
- SAD = Standard American Diet (to be avoided)
- Regain Your Brain – Trailer - $0 online series
- ApoE4.Info – The Alzheimer's Gene Resource
- ApoE4.Info - Forums
- Dr. Dale Bredesen | The End of Alzheimer's | MPI Cognition
- APOE-4 allele. It is known that carrying this allele is associated with increased risk for Alzheimer's disease. APOE-4 allele (the APOE-4 allele is present in about 20-25% of the United States population). It is easy to test for this allele without involvement of a healthcare provider by simply trying a genetic testing product like 23 and Me.
- The Sleep Doctor - Michael J. Breus, PhD
- EndFatigue
- SHINE Protocol = Sleep + Hormones + Infection + Nutrition + Exercise (with sunshine)
- If a medical product/procedure is not profitable, it can't go through the FDA (USA) approval process. Inexpensive or natural/holistic products are not discussed in medical schools.
- Cures A-Z on the App Store
- Eating chocolate (one small square per day) is as much as 25 times more likely to prevent a heart attack than taking a Statin. (Unless you have a known heart disease.)
- Curamin (not to be confused with Curcumin) will reduce pain if taken 2-3 times a day for six weeks. More pain relief than Celebrex.
- Curcumin (included in CuraMed) will help with depression. More effective than anti-depressant drugs.
- Neurogenesis: How to Change Your Brain | HuffPost
- C-Health: Your Health and Wellness Source - powered by MediResource
- Canadian Health Network - Réseau canadien de la santé
- Canadian Living
- CNN
- CNN.com - Transcripts - Dr. Sanjay Gupta - A look at Alzheimer's Disease
- CNN.com - Transcripts - Dr. Sanjay Gupta - A Look at Treatments for Alzheimer's Disease
- Study: Older adults improve memory through exercise – The Chart - CNN.com Blogs - 2011-01-31
- How to cut your risk of memory loss - CNN.com
- Dummies
- EverythingZoomer
- Health Canada - Santé Canada
- HealthAfter50.com | UC Berkley School of Public Health | Health and Welness Alerts
- healthfinder® - your guide to reliable health information
- MayoClinic.com - Alzheimer's disease
- Montreal Gazette
- Dr. Rishanthi Sivakumaran creates reference points on the head of Micheline Morency at the Transcranial Magnetic Stimulation laboratory at the McGill research
- In Nigeria, Justice was once full of beans - By JOE SCHWARCZ, Freelance June 4, 2011
- http://www.montrealgazette.com/health/Nigeria+Justice+once+full+beans/4892260/story.html#ixzz1P78lIWd1
- Acetylcholine, a key neurotransmitter needed to relay information from nerve to muscle cells
- The Calabar bean can serve as an antidote to atropine, the belladonna poison
- Since Alzheimer's disease is also characterized by an acetylcholine deficiency, physostigmine and its derivatives are also being explored in its treatment.
- National Institutes of Health (NIH)
- National Library of Medicine - National Institutes of Health
- NLM Support Center - National Library of Medicine
- Neurology.org
- NY Times -|$$$|- (CDN$20/4weeks)
- Is Alzheimer’s Type 3 Diabetes?
- NYTimes.com - Signs of Cognitive Decline and Alzheimer’s Are Seen in Gait -|$$$|- (CDN$20/4weeks)
- Alzheimer's Disease - Symptoms, Diagnosis, Treatment of Alzheimer's Disease - NY Times Health Information -|$$$|- (CDN$20/4weeks)
- How Exercise May Keep Alzheimer's at Bay - NYTimes.com -|$$$|- (CDN$20/4weeks)
- PLoS ONE : accelerating the publication of peer-reviewed science
- Prevention Magazine
- Smoking
- What Impact Does Smoking Have on Dementia Risk?
- WebMD
- Zoomer
- EverythingZoomer.com
- New Alzheimer's Drug Becomes First to Reportedly Slow Cognitive Decline in Trial - Everything Zoomer - donanemab
- Alzheimer's Awareness: Debunking 10 Common Myths - Everything Zoomer
- Omitted in this article: (see the Comments section at the bottom of the article)
- Alzheimer's may be a form of diabetes
- blood sugar levels, insulin levels
- dietary carbohydrates (low fat diets) vs. saturated fats (not trans-fats)(low carb diets)
- Omitted in this article: (see the Comments section at the bottom of the article)
- 10 Warning Signs of Alzheimer's - Everything Zoomer
- Memory loss that affects day-to-day function
- Difficulty performing familiar tasks
- Problems with language
- Disorientation of time and place
- Poor or decreased judgment
- Problems with abstract thinking
- Misplacing things
- Changes in mood and behaviour
- Changes in personality
- Loss of initiative
- see also: Dementia
